Symbol
Name
ID

Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
MGI:102469

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

increased B cell apoptosis

abnormal osteoclast differentiation

decreased B cell proliferation

abnormal class switch recombination

increased double-negative T cell number

decreased double-positive T cell number

abnormal lymphocyte cell number

decreased B-1a cell number

decreased B cell number

decreased lymphocyte cell number

decreased osteoclast cell number

abnormal lymphocyte physiology

abnormal B cell physiology

abnormal immunoglobulin level

increased IgA level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgM level

increased IgM level

decreased immunoglobulin level

increased immunoglobulin level

abnormal marginal zone B cell physiology

abnormal T cell physiology

abnormal T-helper 2 physiology

abnormal immune system physiology

abnormal interferon-gamma secretion

increased interleukin-10 secretion

abnormal interleukin-2 secretion

decreased interleukin-2 secretion

decreased interleukin-4 secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

Availability

Mouse Genotype

Nfatc1^tm1Glm/Nfatc1^tm2Glm

Nfatc1^tm1Rao/Nfatc1^tm1Rao
Cd79a^tm1(cre)Reth/Cd79a⁺ (conditional)

Nfatc1^tm1Rao/Nfatc1^tm1Rao
Tg(Fcer2a-cre)5Mbu/0 (conditional)

Nfatc1^tm3Glm/Nfatc1^tm3Glm
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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